kernscr

kernscr is a R package which performs score test for genetic pathway analysis in the presence of semi-competing risks.

Neykov M, Hejblum BP and Sinnott JA (2018). Kernel Machine Score Test for Pathway Analysis in the Presence of Semi-Competing Risks. Statistical Methods in Medical Research, 27(4): 1099-1114. <doi: 10.1177/0962280216653427>

Installation

You can install the released version of kernscr from CRAN with:

install.packages("kernscr")

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Version

Install

install.packages('kernscr')

Monthly Downloads

201

Version

1.0.6

License

GPL-2 | file LICENSE

Maintainer

Boris P. Hejblum

Last Published

April 17th, 2023

Functions in kernscr (1.0.6)

compute_all_tests

Testing pathway risk association

dM

VTM

cancer_pathways

70 pathways from MSigDB c2CP

kernscr: a package to perform Kernel Machine Score Test for Pathway Analysis in the Presence of Semi-Competing Risks

findRhoInterval

Find an interval constraining the rho parameter for a non linear kernel

kernelEval

Evaluation of kernels

M_vec

M vector and its perturbation

Ahat

Ahat computation

sim_SCR_data

Data Simulation Function

lambda

Lambda and its perturbation

PI_2

plot_kernscr_methodsplit

Plotting functions used in the manuscript