kinship2 (version 1.3.1)

minnbreast: Minnesota Breast Cancer Study

Description

Data from the Minnesota Breast Cancer Family Study. This contains extended pedigrees from 426 families, each identified by a single proband in 1945-52, with follow up for incident breast cancer.

Usage

data(minnbreast)

source

Authors of the study

Details

The original study was conducted by Dr. Elving Anderson at the Dight Institute for Human Genetics at the University of Minnesota. From 1944 to 1952, 544 sequential breast cancer cases seen at the University Hospital were enrolled, and information gathered on parents, siblings, offspring, aunts/uncles, and grandparents with the goal of understanding possible familial aspects of brest cancer. In 1991 the study was resurrected by Dr. Tom Sellers. Of the original 544 he excluded 58 prevalent cases, along with another 19 who had less than 2 living relatives at the time of Dr Anderson's survey. Of the remaining 462 families 10 had no living members, 23 could not be located and 8 refused, leaving 426 families on whom updated pedigrees were obtained. This gave a study with 13351 males and 12699 females (5183 marry-ins). Primary questions were the relationship of early life exposures, breast density, and pharmacogenomics on incident breast cancer risk.

For a subset of the families data was gathered on prostate cancer risk for male subjects via questionairres sent to men over 40. Other than this, data items other than parentage are limited to the female subjects.

In ___ a second phase of the study was instituted. The pedigrees were further extended to the numbers found in this data set, and further data gathered by questionairre.

The second data set contains time dependent covariates and so is coded in a (start, stop) style. It is also more refined with respect to marry-ins to the study, whose observed breast cancer risk does not start until they join the family.

References

Epidemiologic and genetic follow-up study of 544 Minnesota breast cancer families: design and methods. Sellers TA, Anderson VE, Potter JD, Bartow SA, Chen PL, Everson L, King RA, Kuni CC, Kushi LH, McGovern PG, et al. Genetic Epidemiology, 1995; 12(4):417-29.

Evaluation of familial clustering of breast and prostate cancer in the Minnesota Breast Cancer Family Study. Grabrick DM, Cerhan JR, Vierkant RA, Therneau TM, Cheville JC, Tindall DJ, Sellers TA. Cancer Detect Prev. 2003; 27(1):30-6.

Risk of breast cancer with oral contraceptive use in women with a family history of breast cancer. Grabrick DM, Hartmann LC, Cerhan JR, Vierkant RA, Therneau TM, Vachon CM, Olson JE, Couch FJ, Anderson KE, Pankratz VS, Sellers TA. JAMA. 2000; 284(14):1791-8.

Examples

data(minnbreast)
breastped <- with(minnbreast, pedigree(id, fatherid, motherid, sex,
                  status=(cancer& !is.na(cancer)), affected=proband,
                   famid=famid))
plot(breastped["8"])  #plot family 8, proband is solid, slash for cancers
#Note that breastped[8] is a different family, since ids are not 1,2,3,...