VPA: Valproic acid (VPA) data set

Description

A mouse split-plot experiment with two treatments.

Arguments

Format

A data frame with 24 rows and 5 variables:

Details

Six pregnant female mice were randomly assigned to receive an injection of valproic acid (n = 3) or saline (n = 3). The offspring of these mice (n = 24) were then randomly assigned to receive an injection of the glutamate receptor antagonist MPEP (n = 12) or saline (n = 12). There are two levels of randomisation: the pregnant females and their offspring.

This is a subset of the full data set from Mehta et al., which contained fourteen litters. The litters were selected to have an equal sample size across all conditions for illustrative purposes. The complete data can be found in the supplementary material of Lazic and Essioux (2013).

References

Mehta MV, Gandal MJ, Siegel SJ (2011). mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autism. PLoS ONE 6(10):e26077.

Lazic SE, Essioux L (2013). Improving basic and translational science by accounting for litter-to-litter variation in animal models. BMC Neuroscience 14:37.