fstp2seq

Obtains the adjusted p-values for the stepwise gatekeeping
procedures for multiplicity problems involving two sequences of
hypotheses.

Performs power and sample size calculation for non-proportional hazards model using the Fleming-Harrington family of weighted log-rank tests. The sequentially calculated log-rank test score statistics are assumed to have independent increments as characterized in Anastasios A. Tsiatis (1982) <doi:10.1080/01621459.1982.10477898>. The mean and variance of log-rank test score statistics are calculated based on Kaifeng Lu (2021) <doi:10.1002/pst.2069>. The boundary crossing probabilities are calculated using the recursive integration algorithm described in Christopher Jennison and Bruce W. Turnbull (2000, ISBN:0849303168). The package can also be used for continuous, binary, and count data. For continuous data, it can handle missing data through mixed-model for repeated measures (MMRM). In crossover designs, it can estimate direct treatment effects while accounting for carryover effects. For binary data, it can design Simon's 2-stage, modified toxicity probability-2 (mTPI-2), and Bayesian optimal interval (BOIN) trials. For count data, it can design group sequential trials for negative binomial endpoints with censoring. Additionally, it facilitates group sequential equivalence trials for all supported data types. Moreover, it can design adaptive group sequential trials for changes in sample size, error spending function, number and spacing or future looks. Finally, it offers various options for adjusted p-values, including graphical and gatekeeping procedures.

Kaifeng Lu

lrstat

Power and Sample Size Calculation for Non-Proportional Hazards
and Beyond

fstp2seq function

<dl><dt>p</dt>
<dd>The raw p-values for elementary hypotheses.</dd>
<dt>gamma</dt>
<dd>The truncation parameters for each family. The truncation
parameter for the last family is automatically set to 1.</dd>
<dt>test</dt>
<dd>The component multiple testing procedure. It is either "Holm"
or "Hochberg", and it defaults to "Hochberg".</dd>
<dt>retest</dt>
<dd>Whether to allow retesting. It defaults to <code>TRUE</code>.</dd></dl>

Arguments

Kaifeng Lu, <a href="/link/kaifenglu%40gmail.com?package=lrstat&version=0.2.13" data-mini-rdoc="lrstat::kaifenglu@gmail.com">kaifenglu@gmail.com</a>

Author

Adjusted p-Values for Stepwise Testing Procedures for Two Sequences — fstp2seq

<dl>

<dt>p</dt>
<dd>The raw p-values for elementary hypotheses.</dd>


<dt>gamma</dt>
<dd>The truncation parameters for each family. The truncation
parameter for the last family is automatically set to 1.</dd>


<dt>test</dt>
<dd>The component multiple testing procedure. It is either "Holm"
or "Hochberg", and it defaults to "Hochberg".</dd>


<dt>retest</dt>
<dd>Whether to allow retesting. It defaults to <code>TRUE</code>.</dd>

</dl>

Kaifeng Lu, <a href='mailto:kaifenglu@gmail.com'>kaifenglu@gmail.com</a>

fstp2seq: Adjusted p-Values for Stepwise Testing Procedures for Two Sequences

Description

Usage

Value

Arguments

Author

Examples