lrstat (version 0.2.13)

nevent2: Number of Subjects Having an Event by Calendar Time

Description

Obtains the number of subjects having an event by given calendar times for each treatment group.

Usage

nevent2(
  time = NA_real_,
  allocationRatioPlanned = 1,
  accrualTime = 0L,
  accrualIntensity = NA_real_,
  piecewiseSurvivalTime = 0L,
  lambda1 = NA_real_,
  lambda2 = NA_real_,
  gamma1 = 0L,
  gamma2 = 0L,
  accrualDuration = NA_real_,
  minFollowupTime = NA_real_,
  maxFollowupTime = NA_real_
)

Value

A matrix of the number of patients having an event at the specified calendar times (row) for each treatment group (column).

Arguments

time

A vector of calendar times at which to calculate the number of patients having an event.

allocationRatioPlanned

Allocation ratio for the active treatment versus control. Defaults to 1 for equal randomization.

accrualTime

A vector that specifies the starting time of piecewise Poisson enrollment time intervals. Must start with 0, e.g., c(0, 3) breaks the time axis into 2 accrual intervals: [0, 3) and [3, Inf).

accrualIntensity

A vector of accrual intensities. One for each accrual time interval.

piecewiseSurvivalTime

A vector that specifies the starting time of piecewise exponential survival time intervals. Must start with 0, e.g., c(0, 6) breaks the time axis into 2 event intervals: [0, 6) and [6, Inf). Defaults to 0 for exponential distribution.

lambda1

A vector of hazard rates for the event for the active treatment group. One for each analysis time interval.

lambda2

A vector of hazard rates for the event for the control group. One for each analysis time interval.

gamma1

The hazard rate for exponential dropout, or a vector of hazard rates for piecewise exponential dropout for the active treatment group.

gamma2

The hazard rate for exponential dropout, or a vector of hazard rates for piecewise exponential dropout for the control group.

accrualDuration

Duration of the enrollment period.

minFollowupTime

Follow-up time for the last enrolled subject.

maxFollowupTime

Follow-up time for the first enrolled subject. For fixed follow-up, maxFollowupTime = minFollowupTime. For variable follow-up, maxFollowupTime = accrualDuration + minFollowupTime.

Author

Kaifeng Lu,

Examples

# Piecewise accrual, piecewise exponential survivals, and 5% dropout by
# the end of 1 year.
nevent2(time = c(9, 24), allocationRatioPlanned = 1,
        accrualTime = c(0, 3), accrualIntensity = c(10, 20),
        piecewiseSurvivalTime = c(0, 6),
        lambda1 = c(0.0533, 0.0309), lambda2 = c(0.0533, 0.0533),
        gamma1 = -log(1-0.05)/12, gamma2 = -log(1-0.05)/12,
        accrualDuration = 12, minFollowupTime = 18,
        maxFollowupTime = 30)