meta (version 6.5-0)

labbe.metabin: L'Abbé plot for meta-analysis with binary outcomes

Description

Draw a L'Abbé plot for meta-analysis with binary outcomes.

Usage

# S3 method for metabin
labbe(
  x,
  xlim,
  ylim,
  xlab = NULL,
  ylab = NULL,
  TE.common = x$TE.common,
  TE.random = x$TE.random,
  common = x$common,
  random = x$random,
  backtransf = x$backtransf,
  axes = TRUE,
  pch = 21,
  text = NULL,
  cex = 1,
  col = "black",
  bg = "lightgray",
  lwd = 1,
  lwd.common = lwd,
  lwd.random = lwd,
  lty.common = 2,
  lty.random = 9,
  col.common = col,
  col.random = col,
  nulleffect = TRUE,
  lwd.nulleffect = lwd,
  col.nulleffect = "lightgray",
  sm = x$sm,
  weight,
  studlab = FALSE,
  cex.studlab = 0.8,
  pos.studlab = 2,
  label.e = x$label.e,
  label.c = x$label.c,
  warn.deprecated = gs("warn.deprecated"),
  TE.fixed,
  fixed,
  lwd.fixed,
  lty.fixed,
  col.fixed,
  ...
)
# S3 method for default
labbe(
  x,
  y,
  xlim,
  ylim,
  xlab = NULL,
  ylab = NULL,
  TE.common = NULL,
  TE.random = NULL,
  common = !is.null(TE.common),
  random = !is.null(TE.random),
  backtransf = TRUE,
  axes = TRUE,
  pch = 21,
  text = NULL,
  cex = 1,
  col = "black",
  bg = "lightgray",
  lwd = 1,
  lwd.common = lwd,
  lwd.random = lwd,
  lty.common = 2,
  lty.random = 9,
  col.common = col,
  col.random = col,
  nulleffect = TRUE,
  lwd.nulleffect = lwd,
  col.nulleffect = "lightgray",
  sm = "",
  weight,
  studlab = FALSE,
  cex.studlab = 0.8,
  pos.studlab = 2,
  label.e = NULL,
  label.c = NULL,
  warn.deprecated = gs("warn.deprecated"),
  TE.fixed,
  fixed,
  lwd.fixed,
  lty.fixed,
  col.fixed,
  ...
)

Arguments

x

An object of class metabin. Alternatively, the x coordinates of points of the L'Abbé plot.

xlim

The x limits (min, max) of the plot.

ylim

The y limits (min, max) of the plot.

xlab

A label for the x-axis.

ylab

A label for the y-axis.

TE.common

A numeric or vector specifying combined common effect estimate(s).

TE.random

A numeric or vector specifying combined random effects estimate(s).

common

A logical indicating whether the common effect estimate should be plotted.

random

A logical indicating whether the random effects estimate should be plotted.

backtransf

A logical indicating which values should be printed on x- and y-axis (see Details).

axes

A logical indicating whether axes should be drawn on the plot.

pch

The plotting symbol used for individual studies.

text

A character vector specifying the text to be used instead of plotting symbol.

cex

The magnification to be used for plotting symbol.

col

A vector with colour of plotting symbols.

bg

A vector with background colour of plotting symbols (only used if pch in 21:25).

lwd

The line width.

lwd.common

The line width(s) for common effect estimate(s) (if common is not NULL or FALSE).

lwd.random

The line width(s) for random effects estimate(s) (if random is not NULL or FALSE).

lty.common

Line type(s) for common effect estimate(s).

lty.random

Line type(s) for random effects estimate(s).

col.common

Colour of line(s) for common effect estimate(s).

col.random

Colour of line(s) for random effects estimate(s).

nulleffect

A logical indicating whether line for null effect should be added to the plot..

lwd.nulleffect

Width of line for null effect.

col.nulleffect

Colour of line for null effect.

sm

A character string indicating underlying summary measure, i.e., "RD", "RR", "OR", or "ASD".

weight

Either a numeric vector specifying relative sizes of plotting symbols or a character string indicating which type of plotting symbols is to be used for individual treatment estimates. One of missing (see Details), "same", "common", or "random", can be abbreviated. Plot symbols have the same size for all studies or represent study weights from common effect or random effects model.

studlab

A logical indicating whether study labels should be printed in the graph. A vector with study labels can also be provided (must be of same length as x$event.e then).

cex.studlab

Size of study labels.

pos.studlab

Position of study labels, see argument pos in text.

label.e

Label for experimental group.

label.c

Label for control group.

warn.deprecated

A logical indicating whether warnings should be printed if deprecated arguments are used.

TE.fixed

Deprecated argument (replaced by 'TE.common').

fixed

Deprecated argument (replaced by 'common').

lwd.fixed

Deprecated argument (replaced by 'lwd.common').

lty.fixed

Deprecated argument (replaced by 'lty.common').

col.fixed

Deprecated argument (replaced by 'col.common').

...

Graphical arguments as in par may also be passed as arguments.

y

The y coordinates of the L'Abbé plot, if argument x is not an object of class metabin.

Author

Guido Schwarzer

Details

A L'Abbé plot is a scatter plot with the risk in the control group on the x-axis and the risk in the experimental group on the y-axis (L'Abbé et al., 1987). It can be used to evaluate heterogeneity in meta-analysis. Furthermore, this plot can aid to choose a summary measure (odds ratio, risk ratio, risk difference) that will result in more consistent results (Jiménez et al., 1997; Deeks, 2002).

If argument backtransf is TRUE (default), event probabilities will be printed on x- and y-axis. Otherwise, transformed event probabilities will be printed as defined by the summary measure, i.e., log odds of probabilities for odds ratio as summary measure (sm = "OR"), log probabilities for sm = "RR", and arcsine-transformed probabilities for sm = "ASD".

If common is TRUE, the estimate of the common effct model is plotted as a line. If random is TRUE, the estimate of the random effects model is plotted as a line.

Information from object x is utilised if argument weight is missing. Weights from the common effect model are used (weight = "common") if argument x$common is TRUE; weights from the random effects model are used (weight = "random") if argument x$random is TRUE and x$common is FALSE.

References

Deeks JJ (2002): Issues in the selection of a summary statistic for meta-analysis of clinical trials with binary outcomes. Statistics in Medicine, 21, 1575--600

Jiménez FJ, Guallar E, Martín-Moreno JM (1997): A graphical display useful for meta-analysis. European Journal of Public Health, 1, 101--5

L'Abbé KA, Detsky AS, O'Rourke K (1987): Meta-analysis in clinical research. Annals of Internal Medicine, 107, 224--33

See Also

metabin

Examples

data(Olkin1995)
m1 <- metabin(ev.exp, n.exp, ev.cont, n.cont,
  data = Olkin1995, studlab = paste(author, year),
  sm = "RR", method = "I")

# L'Abbe plot for risk ratio
#
labbe(m1)

# L'Abbe plot for odds ratio
#
labbe(m1, sm = "OR")
# same plot
labbe(update(m1, sm = "OR"))

# L'Abbe plot for risk difference
#
labbe(m1, sm = "RD")

# L'Abbe plot on log odds scale
#
labbe(m1, sm = "OR", backtransf = FALSE)

# L'Abbe plot for odds ratio with coloured lines for various
# treatment effects (defined as log odds ratios)
#
mycols <- c("blue", "yellow", "green", "red", "green", "yellow", "blue")
labbe(m1, sm = "OR", random = FALSE,
  TE.common = log(c(1 / 10, 1 / 5, 1 / 2, 1, 2, 5, 10)),
  col.common = mycols, lwd.common = 2)

# L'Abbe plot on log odds scale with coloured lines for various
# treatment effects (defined as log odds ratios)
#
labbe(m1, sm = "OR", random = FALSE, backtransf = FALSE,
  TE.common = log(c(1 / 10, 1 / 5, 1 / 2, 1, 2, 5, 10)),
  col.common = mycols, lwd.common = 2)