metafor (version 3.0-2)

dat.egger2001: Studies on the Effectiveness of Intravenous Magnesium in Acute Myocardial Infarction

Description

Results from 16 trials examining the effectiveness of intravenous magnesium in the prevention of death following acute myocardial infarction.

Usage

dat.egger2001

Format

The data frame contains the following columns:

id	numeric	trial id number
study	character	first author or trial name
year	numeric	publication year
ai	numeric	number of deaths in the magnesium group
n1i	numeric	number of patients in the magnesium group
ci	numeric	number of deaths in the control group

Details

The dataset includes the results from 16 randomized clinical trials that examined the effectiveness of intravenous magnesium in the prevention of death following acute myocardial infarction. Studies 1-7 were included in the meta-analyses by Teo et al. (1991) and Horner (1992) and were combined with the results from the LIMIT-2 trial (Woods et al., 1992) in Yusuf et al. (1993), suggesting that magnesium is an effective treatment for reducing mortality. However, the results from the ISIS-4 mega trial (ISIS-4 Collaborative Group, 1995) indicated no reduction in mortality with magnesium treatment. Publication bias has been suggested as one possible explanation for the conflicting findings (Egger & Davey Smith, 1995).

The present dataset includes some additional trials and are based on Table 18.2 from Egger, Davey Smith, and Altman (2001).

References

Egger, M., & Davey Smith, G. (1995). Misleading meta-analysis: Lessons from “an effective, safe, simple” intervention that wasn't. British Medical Journal, 310(6982), 752--754. https://doi.org/10.1136/bmj.310.6982.752

Horner, S. M. (1992). Efficacy of intravenous magnesium in acute myocardial infarction in reducing arrhythmias and mortality: Meta-analysis of magnesium in acute myocardial infarction. Circulation, 86(3), 774--779. https://doi.org/10.1161/01.cir.86.3.774

ISIS-4 Collaborative Group (1995). ISIS-4: A randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58,050 patients with suspected acute myocardial infarction. Lancet, 345(8951), 669--685. https://doi.org/10.1016/S0140-6736(95)90865-X

Teo, K. K., Yusuf, S., Collins, R., Held, P. H., & Peto, R. (1991). Effects of intravenous magnesium in suspected acute myocardial infarction: Overview of randomised trials. British Medical Journal, 303(6816), 1499--1503. https://doi.org/10.1136/bmj.303.6816.1499

Woods, K. L., Fletcher, S., Roffe, C., & Haider, Y. (1992). Intravenous magnesium sulphate in suspected acute myocardial infarction: Results of the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2). Lancet, 339(8809), 1553--1558. https://doi.org/10.1016/0140-6736(92)91828-v

Yusuf, S., Teo, K., & Woods, K. (1993). Intravenous magnesium in acute myocardial infarction: An effective, safe, simple, and inexpensive treatment. Circulation, 87(6), 2043--2046. https://doi.org/10.1161/01.cir.87.6.2043

See Also

dat.li2007

Examples

# NOT RUN {
### copy data into 'dat' and examine data
dat <- dat.egger2001
dat

### meta-analysis of trials 1-7 using Peto's method (as in Teo et al., 1991)
res <- rma.peto(ai=ai, n1i=n1i, ci=ci, n2i=n2i, data=dat, subset=1:7)
print(res, digits=2)

### meta-analysis of trials 1-7 and LIMIT-2 (as in Yusuf et al., 1993)
res <- rma.peto(ai=ai, n1i=n1i, ci=ci, n2i=n2i, data=dat, subset=c(1:7,14))
print(res, digits=2)

### meta-analysis of all trials except ISIS-4
res <- rma.peto(ai=ai, n1i=n1i, ci=ci, n2i=n2i, data=dat, subset=-16)
print(res, digits=2)
predict(res, transf=exp, digits=2)

### meta-analysis of all trials including ISIS-4
res <- rma.peto(ai=ai, n1i=n1i, ci=ci, n2i=n2i, data=dat)
print(res, digits=2)
predict(res, transf=exp, digits=2)

### contour-enhanced funnel plot centered at 0
funnel(res, refline=0, level=c(90, 95, 99), shade=c("white", "gray", "darkgray"))
# }