dat.lung

<p>A data set based on a meta-analysis comparing overall survival times between individuals randomized to experimental arms and comparator arms in randomized trials for non-small cell lung cancer therapies (Iskander et al. 2024).</p>

datasets

Implements several methods to meta-analyze studies that report the
sample median of the outcome. The methods described by
McGrath et al. (2019) <doi:10.1002/sim.8013>,
Ozturk and Balakrishnan (2020) <doi:10.1002/sim.8738>, and
McGrath et al. (2020a) <doi:10.1002/bimj.201900036> can be
applied to directly meta-analyze the median or difference of medians between
groups. Additionally, a number of methods (e.g., McGrath et al. (2020b)
<doi:10.1177/0962280219889080>, Cai et al. (2021)
<doi:10.1177/09622802211047348>, and McGrath et al. (2023)
<doi:10.1177/09622802221139233>) are implemented to estimate
study-specific (difference of) means and their standard errors in order to
estimate the pooled (difference of) means. Methods for meta-analyzing median
survival times (McGrath et al. (2025) <doi:10.48550/arXiv.2503.03065>) are
also implemented. See McGrath et al. (2024) <doi:10.1002/jrsm.1686> for a
detailed guide on using the package.

Sean McGrath

metamedian

Meta-Analysis of Medians

XiaoFei Zhao

Stephan Katzenschlager

Omer Ozturk

Renata Iskander

Russell Steele

Andrea Benedetti

dat.lung function

<p>A data frame with 30 rows and 11 columns:</p><table class="table">
<tr><td><code>study</code></td><td>National Clinical Trial (NCT) number of the study.</td></tr>
<tr><td><code>n.g1</code></td><td>number of subjects (experimental group).</td></tr>
<tr><td><code>med.g1</code></td><td>median overall survival (experimental group).</td></tr>
<tr><td><code>med.ci.lb.g1</code></td><td>lower confidence interval bound around the median (experimental group).</td></tr>
<tr><td><code>med.ci.ub.g1</code></td><td>upper confidence interval bound around the median (experimental group).</td></tr>
<tr><td><code>med.ci.level.g1</code></td><td>level of the confidence interval (experimental group).</td></tr>
<tr><td><code>n.g2</code></td><td>number of subjects (comparator group).</td></tr>
<tr><td><code>med.g2</code></td><td>median overall survival (comparator group).</td></tr>
<tr><td><code>med.ci.lb.g2</code></td><td>lower confidence interval bound around the median (comparator group).</td></tr>
<tr><td><code>med.ci.ub.g2</code></td><td>upper confidence interval bound around the median (comparator group).</td></tr>
<tr><td><code>med.ci.level.g2</code></td><td>level of the confidence interval (comparator group).</td></tr>
</table><p></p><p></p>

Format

Example data set: Overall survival times in patients with lung cancer — dat.lung

<p>A data frame with 30 rows and 11 columns:</p><table class='table'>
<tr><td><code>study</code></td><td>National Clinical Trial (NCT) number of the study.</td></tr>
<tr><td><code>n.g1</code></td><td>number of subjects (experimental group).</td></tr>
<tr><td><code>med.g1</code></td><td>median overall survival (experimental group).</td></tr>
<tr><td><code>med.ci.lb.g1</code></td><td>lower confidence interval bound around the median (experimental group).</td></tr>
<tr><td><code>med.ci.ub.g1</code></td><td>upper confidence interval bound around the median (experimental group).</td></tr>
<tr><td><code>med.ci.level.g1</code></td><td>level of the confidence interval (experimental group).</td></tr>
<tr><td><code>n.g2</code></td><td>number of subjects (comparator group).</td></tr>
<tr><td><code>med.g2</code></td><td>median overall survival (comparator group).</td></tr>
<tr><td><code>med.ci.lb.g2</code></td><td>lower confidence interval bound around the median (comparator group).</td></tr>
<tr><td><code>med.ci.ub.g2</code></td><td>upper confidence interval bound around the median (comparator group).</td></tr>
<tr><td><code>med.ci.level.g2</code></td><td>level of the confidence interval (comparator group).</td></tr>
</table>



dat.lung: Example data set: Overall survival times in patients with lung cancer

Description

Usage

Arguments

Format

References

`study`	National Clinical Trial (NCT) number of the study.
`n.g1`	number of subjects (experimental group).
`med.g1`	median overall survival (experimental group).
`med.ci.lb.g1`	lower confidence interval bound around the median (experimental group).
`med.ci.ub.g1`	upper confidence interval bound around the median (experimental group).
`med.ci.level.g1`	level of the confidence interval (experimental group).
`n.g2`	number of subjects (comparator group).
`med.g2`	median overall survival (comparator group).
`med.ci.lb.g2`	lower confidence interval bound around the median (comparator group).
`med.ci.ub.g2`	upper confidence interval bound around the median (comparator group).
`med.ci.level.g2`	level of the confidence interval (comparator group).