pkOdeModel2Compartments

numeric representing time in the system

list of state variables ( dose in gut , concentration in plasma , concentration in tissue )

Set of differential equations representing two compartmental pk model with possible Michaelis-Menten kinetics at absorption and clearance
used as interal function

internal


Find optimal microsampling designs for non-compartmental pharacokinetic analysis using a  general simulation methodology:
Algorithm III of Barnett, Helen, Helena Geys, Tom Jacobs, and Thomas Jaki. (2017) "Optimal Designs for Non-Compartmental
Analysis of Pharmacokinetic Studies. (currently unpublished)"
This methodology consist of (1) specifying a pharmacokinetic model
including variability among animals; (2) generating possible sampling times; (3)
evaluating performance of each time point choice on simulated data; (4)
generating possible schemes given a time point choice and additional constraints
and finally (5) evaluating scheme performance on simulated data. The default
settings differ from the article of Barnett and others, in the default pharmacokinetic model used and
the parameterization of variability among animals. Details can be found in the package vignette. A 'shiny'
web application is included, which guides users from model parametrization to
optimal microsampling scheme.

Adriaan Blommaert

microsamplingDesign

Finding Optimal Microsampling Designs for Non-Compartmental
Pharmacokinetic Analysis

Daan Seynaeve

Helen Barnett

Helena Geys

Tom Jacobs

Fetene Tekle

Thomas Jaki

pkOdeModel2Compartments function

Set of differential equations representing two compartmental pk model with possible Michaelis-Menten kinetics at absorption and clearance
used as interal function — pkOdeModel2Compartments

Set of differential equations representing two compartmental pk model with possible Michaelis-Menten kinetics at absorption and clearance
used as interal function

pkOdeModel2Compartments: Set of differential equations representing two compartmental pk model with possible Michaelis-Menten kinetics at absorption and clearance used as interal function

Description

Usage

Arguments