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mixOmics (version 5.0-4)

breast.tumors: Human Breast Tumors Data

Description

This data set contains the expression of 1753 genes in 47 surgical specimens of human breast tumours from 17 different individuals before and after chemotherapy treatment.

Usage

data(breast.tumors)

Arguments

encoding

latin1

source

The Human Breast Tumors dataset is a companion resource for the paper of Perou et al. (2000), and was downloaded from the Stanford Genomics Breast Cancer Consortium Portal http://genome-www.stanford.edu/breast_cancer/molecularportraits/download.shtml

Details

This data consists of 47 breast cancer samples and 1753 cDNA clones pre-selected by P?rez-Enciso et al. (2003) to draw their Fig. 1. The authors selected 47 samples for which there was information at least before or before and after chemotherapy treatment. There were 20 tumours that were microarrayed both before and after treatment.

References

Perez-Enciso, M. and Tenenhaus, M. (2003). Prediction of clinical outcome with microarray data: a partial least squares discriminant analysis (PLS-DA) approach. Human Genetics 112, 581-592.

Perou, C. M., Sorlie, T., Eisen, M. B., van de Rijn, M., Jeffrey, S. S., Rees, C. A., Pollack, J. R., Ross, D. T., Johnsen, H., Akslen, L. A., Fluge, O., Pergamenschikov, A., Williams, C., Zhu, S. X., Lonning, P. E., Borresen-Dale, A. L., Brown, P. O. and Botstein, D. (2000). Molecular portraits of human breast tumours. Nature 406, 747-752.