nutrimouse: Nutrimouse Dataset
Description
The nutrimouse dataset contains the expression measure of 120 genes
potentially involved in nutritional problems and the concentrations of 21 hepatic fatty acids
for forty mice.encoding
latin1source
The nutrimouse dataset was provided by Pascal Martin from
the Toxicology and Pharmacology Laboratory, National Institute for
Agronomic Research, French.Details
The data sets come from a nutrigenomic study in the mouse (Martin et al., 2007)
in which the effects of five regimens with contrasted fatty acid compositions
on liver lipids and hepatic gene expression in mice were considered. Two sets of variables
were acquired on forty mice:
- gene: expressions of 120 genes measured in liver cells, selected (among about 30,000)
as potentially relevant in the context of the nutrition study. These expressions come from
a nylon macroarray with radioactive labelling;
- lipid: concentrations (in percentages) of 21 hepatic fatty acids measured by gas chromatography.
Biological units (mice) were cross-classified according to two factors
experimental design (4 replicates):
- Genotype: 2-levels factor, wild-type (WT) and PPAR$\alpha$-/- (PPAR).
- Diet: 5-levels factor. Oils used for experimental diets preparation were corn and colza oils (50/50) for a reference diet (REF), hydrogenated coconut oil for a saturated fatty acid diet (COC), sunflower oil for an Omega6 fatty acid-rich diet (SUN), linseed oil for an Omega3-rich diet (LIN) and corn/colza/enriched fish oils for the FISH diet (43/43/14).
References
Martin, P. G. P., Guillou, H., Lasserre, F., Dejean, S., Lan, A.,
Pascussi, J.-M., San Cristobal, M., Legrand, P., Besse, P. and Pineau, T. (2007).
Novel aspects of PPAR$\alpha$-mediated regulation of lipid and xenobiotic
metabolism revealed through a multrigenomic study. Hepatology 54, 767-777.