This data set contains the expression measure of 3116
genes and 10 clinical measurements for 64 subjects (rats) that were
exposed to non-toxic, moderately toxic or severely toxic doses of acetaminophen
in a controlled experiment.
Usage
data(liver.toxicity)
Arguments
encoding
latin1
source
The two liver toxicity data sets are a companion resource for the paper of
Bushel et al. (2007), and was downloaded from:
The data come from a liver toxicity study (Bushel et al., 2007) in which
64 male rats of the inbred strain Fisher 344 were exposed to non-toxic (50 or
150 mg/kg), moderately toxic (1500 mg/kg) or severely toxic (2000 mg/kg)
doses of acetaminophen (paracetamol) in a controlled experiment. Necropsies
were performed at 6, 18, 24 and 48 hours after exposure and the mRNA
from the liver was extracted. Ten clinical chemistry measurements of variables
containing markers for liver injury are available for each subject and the
serum enzymes levels are measured numerically. The data were further normalized
and pre-processed by Bushel et al. (2007).
References
Bushel, P., Wolfinger, R. D. and Gibson, G. (2007). Simultaneous clustering of gene
expression data with clinical chemistry and pathological evaluations reveals
phenotypic prototypes. BMC Systems Biology1, Number 15.
Le Cao, K.-A., Rossouw, D., Robert-Granie, C. and Besse, P. (2008). A sparse PLS for variable
selection when integrating Omics data. Statistical Applications in Genetics and Molecular
Biology7, article 35.