The nutrimouse dataset contains the expression measure of 120 genes
potentially involved in nutritional problems and the concentrations of 21 hepatic fatty acids
for forty mice.
data(nutrimouse)A list containing the following components:
genedata frame with 40 observations on 120 numerical variables.
lipiddata frame with 40 observations on 21 numerical variables.
dietfactor of 5 levels containing 40 labels for the diet factor.
genotypefactor of 2 levels containing 40 labels for the diet factor.
The data sets come from a nutrigenomic study in the mouse (Martin et al., 2007) in which the effects of five regimens with contrasted fatty acid compositions on liver lipids and hepatic gene expression in mice were considered. Two sets of variables were acquired on forty mice:
gene: expressions of 120 genes measured in liver cells, selected (among about 30,000) as potentially relevant in the context of the nutrition study. These expressions come from a nylon macroarray with radioactive labelling;
lipid: concentrations (in percentages) of 21 hepatic fatty acids measured by gas chromatography.
Biological units (mice) were cross-classified according to two factors experimental design (4 replicates):
Genotype: 2-levels factor, wild-type (WT) and PPAR\(\alpha\) -/- (PPAR).
Diet: 5-levels factor. Oils used for experimental diets preparation were corn and colza oils (50/50) for a reference diet (REF), hydrogenated coconut oil for a saturated fatty acid diet (COC), sunflower oil for an Omega6 fatty acid-rich diet (SUN), linseed oil for an Omega3-rich diet (LIN) and corn/colza/enriched fish oils for the FISH diet (43/43/14).
Martin, P. G. P., Guillou, H., Lasserre, F., Dejean, S., Lan, A., Pascussi, J.-M., San Cristobal, M., Legrand, P., Besse, P. and Pineau, T. (2007). Novel aspects of PPAR\(\alpha\)-mediated regulation of lipid and xenobiotic metabolism revealed through a multrigenomic study. Hepatology 54, 767-777.