modeldata (version 1.3.0)

steroidogenic_toxicity: Predicting steroidogenic toxicity with assay data

Description

A set of in vitro assays are used to quantify the risk of reproductive toxicity via the disruption of steroidogenic pathways.

Value

A tibble with columns

• class: factor(levels: toxic and nontoxic)

• cyp_11a1: numeric

• cyp_11b1: numeric

• cyp_11b2: numeric

• cyp_17a1: numeric

• cyp_19a1: numeric

• cyp_21a1: numeric

• hsd3b2: numeric

• star: numeric

• progesterone: numeric

• testosterone: numeric

• dhea: numeric

• cortisol: numeric

Details

H295R cells were used to measure the effect with two sets of assay results. The first includes a set of protein measurements on: cytochrome P450 enzymes ("cyp"s), STAR, and 3BHSD2. The second include hormone measurements for DHEA, progesterone, testosterone, and cortisol.

Columns:

• class: factor (levels: 'toxic' and 'nontoxic')

• cyp_11a1: numeric

• cyp_11b1: numeric

• cyp_11b2: numeric

• cyp_17a1: numeric

• cyp_19a1: numeric

• cyp_21a1: numeric

• hsd3b2: numeric

• star: numeric

• progesterone: numeric

• testosterone: numeric

• dhea: numeric

• cortisol: numeric

Examples

data(steroidogenic_toxicity)
str(steroidogenic_toxicity)