hocomoco: MotifDb object containing motif information from Homo Sapiens Comprehensive
Model Collection (HOCOMOCO) of transcription factor (TF) binding models
Description
From the abstract:
"We present the Homo sapiens comprehensive model collection (HOCOMOCO,
http://autosome.ru/HOCOMOCO/, http://cbrc.kaust.edu.sa/hocomoco/)
containing carefully hand-curated TFBS models constructed by integration of
binding sequences obtained by both low- and high-throughput methods. To
construct position weight matrices to represent these TFBS models, we used
ChIPMunk software in four computational modes, including newly developed
periodic positional prior mode associated with DNA helix pitch. We selected
only one TFBS model per TF, unless there was a clear experimental evidence
for two rather distinct TFBS models. We assigned a quality rating to each
model. HOCOMOCO contains 426 systematically curated TFBS models for 401 human
TFs, where 172 models are based on more than one data source."