Mutagenicity assay for 4 doses of a compound (hydroquinone) against a negative (vehicle) control and a positive (active) control (cyclophosphamide).
Hydroquinone was applied in doses of 30, 50, 70, 100 mg/kg, positive control was applied with 25mg/kg.
Counts of micronuclei in polychromatic erythrocytes after 24h are taken as a measure for the potency to induce chromosome damage. Data of male mice are presented
(Hauschke et al., 2005).
Usage
data(Mutagenicity)
Arguments
Format
A data frame with 31 observations on the following 2 variables.
Treatment
a factor with levels Cyclo25, Hydro100, Hydro30, Hydro50, Hydro75, Vehicle
MN
a numeric vector, giving the counts of micronuclei after 24h
References
Hauschke, D, Slacik-Erben, R, Hansen, S, Kaufmann,R (2005).
Biostatistical Assessment of mutagenicity studies by including the positive control.
Biometrical Journal 47, 82-87.