impute_missing: Impute feature value if missing from element-feature pairs
Description
impute_missing() takes as imput a `tbl` formatted as | <element> | <feature> | <value> | <...> | and returns a `tbl` with an edditional adjusted value column. This method uses scaled counts if present.
# S4 method for spec_tbl_df
impute_missing(.data, .element, .feature, .value, .formula)
# S4 method for tbl_df
impute_missing(.data, .element, .feature, .value, .formula)
Arguments
.data
A `tbl` formatted as | <element> | <feature> | <value> | <...> |
.element
The name of the element column
.feature
The name of the feature/gene column
.value
The name of the feature/gene value column
.formula
A formula with no response variable, representing the desired linear model where the first covariate is the factor of interest and the second covariate is the unwanted variation (of the kind ~ factor_of_intrest + batch)
Value
A `tbl` non-sparse value
A `tbl` with imputed abundnce
A `tbl` with imputed abundnce
Details
maturing
This function imputes the value of missing element-feature pair using the median of the element group defined by the formula