grid.sim.internal1

internal

Loading NONMEM (NONlinear Mixed-Effect Modeling, <https://www.iconplc.com/solutions/technologies/nonmem/>) and PSN (Perl-speaks-NONMEM, <https://uupharmacometrics.github.io/PsN/>) output files to extract parameter estimates, provide visual predictive check (VPC) and goodness of fit (GOF) plots, and simulate with parameter uncertainty.

Magnus Astrand

nonmem2R

Loading NONMEM Output Files with Functions for Visual Predictive
Checks (VPC) and Goodness of Fit (GOF) Plots

grid.sim.internal1 function

<dl><dt>n</dt>
<dd>Number of simulations</dd>
<dt>means</dt>
<dd>vector of mean values</dd>
<dt>sigma</dt>
<dd>covariance matrix</dd>
<dt>grid.param</dt>
<dd>the index of the parameter for which a fix grid (from qnorm) is used instead of a simulated grid (rnorm).
If grid.param=NULL ( default) the fix grid will be used for the parameter with largest variance.</dd>
<dt>pure.sim</dt>
<dd>Pure sim or use grid simulation</dd></dl>

Arguments

Internal function — grid.sim.internal1

<dl>

<dt>n</dt>
<dd>Number of simulations</dd>


<dt>means</dt>
<dd>vector of mean values</dd>


<dt>sigma</dt>
<dd>covariance matrix</dd>


<dt>grid.param</dt>
<dd>the index of the parameter for which a fix grid (from qnorm) is used instead of a simulated grid (rnorm).
If grid.param=NULL ( default) the fix grid will be used for the parameter with largest variance.</dd>


<dt>pure.sim</dt>
<dd>Pure sim or use grid simulation</dd>

</dl>

grid.sim.internal1: Internal function

Description

Usage

Value

Arguments