numbat (version 1.4.2)

approx_theta_post: Laplace approximation of the posterior of allelic imbalance theta

Description

Laplace approximation of the posterior of allelic imbalance theta

Usage

approx_theta_post(
  pAD,
  DP,
  p_s,
  lower = 0.001,
  upper = 0.499,
  start = 0.25,
  gamma = 20
)

Arguments

pAD

numeric vector Variant allele depth

DP

numeric vector Total allele depth

p_s

numeric vector Variant allele frequency

lower

numeric Lower bound of theta

upper

numeric Upper bound of theta

start

numeric Starting value of theta

gamma

numeric Gamma parameter of the beta-binomial distribution