Estimates the multipoint log-likelihood, linkage phases and recombination frequencies for a sequence of markers in a given order using seeded phases.
seeded_map(
input.seq,
tol = 1e-04,
phase_cores = 1,
seeds,
verbose = FALSE,
rm_unlinked = FALSE,
parallelization.type = "PSOCK"
)
An object of class sequence
, which is a list containing the
following components:
a vector
containing the
(ordered) indices of markers in the sequence, according to the input file.
a vector
with the linkage phases between markers
in the sequence, in corresponding positions. -1
means that there are
no defined linkage phases.
a vector
with the
recombination frequencies between markers in the sequence. -1
means
that there are no estimated recombination frequencies.
log-likelihood of the corresponding linkage map.
name of the object of class outcross
with the raw
data.
name of the object of class rf_2pts
with the
2-point analyses.
an object of class sequence
.
tolerance for the C routine, i.e., the value used to evaluate convergence.
The number of parallel processes to use when estimating the phase of a marker. (Should be no more than 4)
A vector given the integer encoding of phases for the first N positions of the map
A logical, if TRUE it output progress status information.
When some pair of markers do not follow the linkage criteria,
if TRUE
one of the markers is removed and map is performed again.
one of the supported cluster types. This should be either PSOCK (default) or FORK.
Adapted from Karl Broman (package 'qtl') by Gabriel R A Margarido, gramarga@usp.br and Marcelo Mollinari, mmollina@gmail.com. Modified to use seeded phases by Bastian Schiffthaler bastian.schiffthaler@umu.se
Markers are mapped in the order defined in the object input.seq
. The
best combination of linkage phases is also estimated starting from the first
position not in the given seeds.The multipoint likelihood is calculated
according to Wu et al. (2002b)(Eqs. 7a to 11), assuming that the
recombination fraction is the same in both parents. Hidden Markov chain
codes adapted from Broman et al. (2008) were used.
Broman, K. W., Wu, H., Churchill, G., Sen, S., Yandell, B. (2008) qtl: Tools for analyzing QTL experiments R package version 1.09-43
Jiang, C. and Zeng, Z.-B. (1997). Mapping quantitative trait loci with dominant and missing markers in various crosses from two inbred lines. Genetica 101: 47-58.
Lander, E. S., Green, P., Abrahamson, J., Barlow, A., Daly, M. J., Lincoln, S. E. and Newburg, L. (1987) MAPMAKER: An interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1: 174-181.
Wu, R., Ma, C.-X., Painter, I. and Zeng, Z.-B. (2002a) Simultaneous maximum likelihood estimation of linkage and linkage phases in outcrossing species. Theoretical Population Biology 61: 349-363.
Wu, R., Ma, C.-X., Wu, S. S. and Zeng, Z.-B. (2002b). Linkage mapping of sex-specific differences. Genetical Research 79: 85-96
make_seq
# \donttest{
data(onemap_example_out)
twopt <- rf_2pts(onemap_example_out)
markers <- make_seq(twopt,c(30,12,3,14,2))
seeded_map(markers, seeds = c(4,2))
# }
Run the code above in your browser using DataLab