Receptor occupancy is calculated from posititron emission tomography (PET) data as the treatment-induced relative change in the concentration of available (not occupied) receptors.
occupancy(base, drug, baseSE = NULL, drugSE = NULL, base.drug.corr = 0)is the percent drug occupancy.
is the approximate standard error of the parameter estimate.
is the baseline binding potential (BPND).
is the post-treatment binding potential (BPND).
is the standard error for the baseline BPND.
is the standard error for the post-treatment BPND.
is the user-specified correlation between baseline and post-treatment binding potentials.
Brandon Whitcher bwhitcher@gmail.com
Occupancy is calculated using the straightforward and well-known formula. If the standard errors for the two binding potentials are provided, then the delta method is used to approximate the standard error for the estimate of occupancy.
Cunningham VJ, Rabiner EA, Slifstein M, Laruelle M (2010). Measuring drug occupancy in the absence of a reference region: the Lassen plot re-visited, Journal of Cerebral Blood Flow & Metababolism, 30, 46-50.
Passchier J, Gee A, Willemsen A, Vaalburg W, van Waarde A (2002). Measuring drug-related receptor occupancy with positron emission tomography, Methods, 27, 278-286.
deltamethod