paramlink (version 0.8-3)

randomPed: Random pedigree

Description

Creates a random medical pedigree with specified number of generations.

Usage

randomPed(gen, lambda=2, penetrances=c(0, 1, 1), naff="last.gen", founder.mut=1)

Arguments

gen

an integer in the interval [2,5] indicating the number of generations.

lambda

a positive numeric. For each descendant of the first generation, the number of offspring is sampled from a Poisson distribution with parameter lambda.

penetrances

a numeric of length 3, where for i=1,2,3, penetrances[i] = Prob(affected | i-1 disease alleles).

naff

an integer specifying a lower bound on the number of affected individuals, or the character "last.gen". The latter produce a pedigree where at least one in the yongest generation is affected.

founder.mut

an integer, the number of disease alleles to be distributed among the founders.

Value

• A link{linkdat} object.

Details

The function produce simple pedigrees. Each founder is given at most one disease allele. At least one of the two top founders carries a disease allele.

See Also

linkdat

Examples

plot(randomPed(3))

# gives error message: Not enough founder mutations
randomPed(gen=4, penetrances=c(0,0,1), naff=2, founder.mut=1)