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paramlink (version 1.1-0)

Parametric Linkage and Other Pedigree Analysis in R

Description

A suite of tools for analysing pedigrees with marker data, including parametric linkage analysis, forensic computations, relatedness analysis and marker simulations. The core of the package is an implementation of the Elston-Stewart algorithm for pedigree likelihoods, extended to allow mutations as well as complex inbreeding. Features for linkage analysis include singlepoint LOD scores, power analysis, and multipoint analysis (the latter through a wrapper to the MERLIN software). Forensic applications include exclusion probabilities, genotype distributions and conditional simulations. Data from the Familias software can be imported and analysed in paramlink. Finally, paramlink offers many utility functions for creating, manipulating and plotting pedigrees with or without marker data (the actual plotting is done by the kinship2 package).

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Version

Install

install.packages('paramlink')

Monthly Downloads

391

Version

1.1-0

License

GPL (>= 2)

Maintainer

Magnus Dehli Vigeland

Last Published

March 13th, 2017

Functions in paramlink (1.1-0)

examineKinships

Relatedness estimation
exclusionPower

Power of exclusion
Xped

Example pedigree with X-linked disease pattern.
allGenotypes

Genotype combinations
Familias2linkdat

Convert 'Familias' output to linkdat objects
IBDtriangle

IBD triangle plot
as.data.frame.linkdat

linkdat to data.frame conversion
as.matrix.linkdat

linkdat to matrix conversion
createPedigree

Create simple pedigrees
dominant

Example pedigree for linkage analysis: 23 individuals, 650 SNPs
inbreeding

Inbreeding coefficients and Jacquard coefficients
is.linkdat

Is an object a linkdat object?
linkageSim

Simulate markers linked to a disease locus.
linkdat

linkdat objects
lod

Two-point LOD score
lod.peaks

LOD score peaks
markers

Marker functions
merlin

MERLIN wrappers
modifyPedigree

Modify the pedigree of 'linkdat' objects
setModel

Set, change or display the model parameters for 'linkdat' objects
setPlotLabels

Attach plot labels to a linkdat object
linkdat.utils

linkdat utilities
linkres

S3 methods for class 'linkres'.
plot.linkdat

Plot pedigrees with genotypes
plotPedList

Plot a list of pedigrees.
relationLR

Relationship Likelihood Ratio
likelihood

Pedigree likelihood
linkage.power

Power of a linkage study
oneMarkerDistribution

Genotype probability distribution
paramlink-package

Parametric Linkage and Other Pedigree Analysis in R
simpleSim

Unconditional marker simulation
toyped

Toy pedigree for linkage analysis
setAvailable

Functions for modifying availability vectors
loops

Pedigree loops
markerSim

Marker simulation
randomPed

Random pedigree
readDatfile

Read dat file in LINKAGE format
mergePed

Merge two pedigrees
twoMarkerDistribution

Genotype probability distribution
twoloops

A consanguineous pedigree