calculateBaseline

This function extracts the penetrance data for a specified cancer type, gene, race, and penetrance type
from the provided database.

Implements statistical methods for estimating disease penetrance in
family-based studies. Penetrance refers to the probability of disease§
manifestation in individuals carrying specific genetic variants. The package
provides tools for age-specific penetrance estimation, handling missing data,
and accounting for ascertainment bias in family studies.
Cite as: Kubista, N., Braun, D. & Parmigiani, G. (2024) <doi:10.48550/arXiv.2411.18816>.

Nicolas Kubista

penetrance

Methods for Penetrance Estimation in Family-Based Studies

BayesMendel Lab

calculateBaseline function

<dl><dt>cancer_type</dt>
<dd>The type of cancer for which the risk is being calculated.</dd>
<dt>gene</dt>
<dd>The gene of interest for which the risk is being calculated.</dd>
<dt>race</dt>
<dd>The race of the individual.</dd>
<dt>type</dt>
<dd>The type of penetrance calculation.</dd>
<dt>db</dt>
<dd>The dataset used for the calculation, containing penetrance data.</dd></dl>

Arguments

Calculate Baseline Risk — calculateBaseline

<dl>

<dt>cancer_type</dt>
<dd>The type of cancer for which the risk is being calculated.</dd>


<dt>gene</dt>
<dd>The gene of interest for which the risk is being calculated.</dd>


<dt>race</dt>
<dd>The race of the individual.</dd>


<dt>type</dt>
<dd>The type of penetrance calculation.</dd>


<dt>db</dt>
<dd>The dataset used for the calculation, containing penetrance data.</dd>

</dl>

calculateBaseline: Calculate Baseline Risk

Description

Usage

Value

Arguments