drawEmpirical

This function draws ages using the inverse CDF method from empirical density data,
based on sex and whether the individual was tested.

Implements statistical methods for estimating disease penetrance in
family-based studies. Penetrance refers to the probability of disease§
manifestation in individuals carrying specific genetic variants. The package
provides tools for age-specific penetrance estimation, handling missing data,
and accounting for ascertainment bias in family studies.
Cite as: Kubista, N., Braun, D. & Parmigiani, G. (2024) <doi:10.48550/arXiv.2411.18816>.

Nicolas Kubista

penetrance

Methods for Penetrance Estimation in Family-Based Studies

BayesMendel Lab

drawEmpirical function

<dl><dt>empirical_density</dt>
<dd>A list of density objects containing the empirical density of ages for different groups.</dd>
<dt>sex</dt>
<dd>Numeric, the sex of the individual (1 for male, 2 for female).</dd>
<dt>tested</dt>
<dd>Logical, indicating whether the individual was tested (has a non-NA 'geno' value).</dd>
<dt>sex_specific</dt>
<dd>Logical, indicating whether the imputation should be sex-specific. Default is TRUE.</dd></dl>

Arguments

Draw Ages Using the Inverse CDF Method from Empirical Density — drawEmpirical

<dl>

<dt>empirical_density</dt>
<dd>A list of density objects containing the empirical density of ages for different groups.</dd>


<dt>sex</dt>
<dd>Numeric, the sex of the individual (1 for male, 2 for female).</dd>


<dt>tested</dt>
<dd>Logical, indicating whether the individual was tested (has a non-NA 'geno' value).</dd>


<dt>sex_specific</dt>
<dd>Logical, indicating whether the imputation should be sex-specific. Default is TRUE.</dd>

</dl>

drawEmpirical: Draw Ages Using the Inverse CDF Method from Empirical Density

Description

Usage

Value

Arguments