RDI

The RDI package is part of the Immcantation analysis framework for Adaptive Immune Receptor Repertoire sequencing (AIRR-seq) and provides an methods for visualizing and calculating the Repertoire Dissimilarity Index (RDI).

The Repertoire Dissimilarity Index is a non-parametric method for directly comparing sequencing repertoires, with the goal of rigorously quantifying differences in V, D, and J gene segment utilization. This method uses a bootstrapped subsampling approach to account for variance in sequencing depth, and, coupled with a data simulation approach, allows for direct quantification of the average variation between repertoires.

Contact

For help and questions please contact the Immcantation Group or use the issue tracker.

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Install

install.packages('rdi')

Monthly Downloads

254

Version

1.0.0

License

CC BY-SA 4.0

Last Published

May 7th, 2018

Functions in rdi (1.0.0)