replicateBE (version 1.1.3)

TRRT.RTTR.TTRR.RRTT: Reference Dataset for TRRT|RTTR|TTRR|RRTT Designs

Description

Dataset from the public domain to be evaluated by method.A() and/or method.B().

Format

• Reference Dataset 24 40 subjects (one completely missing). Unbalanced (nine subjects in sequence TRRT and ten in each of the other three) and complete. Two outliers (subject 3 in sequence RTTR and subject 30 in sequence TTRR). A data frame with 160 observations on the following 5 variables:

  rds24

  subject	a factor with 40 levels: 1, 2, …, 932
  period	a factor with 4 levels: 1, 2, 3, 4
  sequence	a factor with 4 levels: TRRT, RTTR, TTRR, RRTT
  treatment	a factor with 2 levels: T, R

Details

Dataset

N

(%)

Evaluation

References

U.S. Food and Drug Administration, Center for Drug Evaluation and Research. Bioequivalence Studies. Rockville, 1997. bioequivalence study files (archived 2017-07-23)

Examples

# NOT RUN {
str(rds24)
row <- c(13:16, 9:12, 1:4, 5:8)
rds24[row, ]
summary(rds24[2:5])
# }