createSaemixObject

createSaemixObject.empty

createSaemixObject.initial

Create saemix objects either with empty results or with parameters set by the user.
This is an internal function used as a preliminary step to obtain predictions for new data
and is not intended to be used directly.

methods

The 'saemix' package implements the Stochastic Approximation EM algorithm for parameter estimation in (non)linear mixed effects models. The SAEM algorithm (i) computes the maximum likelihood estimator of the population parameters, without any approximation of the model (linearisation, quadrature approximation,...), using the Stochastic Approximation Expectation Maximization (SAEM) algorithm, (ii) provides standard errors for the maximum likelihood estimator (iii) estimates the conditional modes, the conditional means and the conditional standard deviations of the individual parameters, using the Hastings-Metropolis algorithm (see Comets et al. (2017) <doi:10.18637/jss.v080.i03>). Many applications of SAEM in agronomy, animal breeding and PKPD analysis have been published by members of the Monolix group. The full PDF documentation for the package including references about the algorithm and examples can be downloaded on the github of the IAME research institute for 'saemix': <https://github.com/iame-researchCenter/saemix/blob/7638e1b09ccb01cdff173068e01c266e906f76eb/docsaem.pdf>.

Emmanuelle Comets

saemix

Stochastic Approximation Expectation Maximization (SAEM)
Algorithm

Audrey Lavenu

Marc Lavielle

Belhal Karimi

Maud Delattre

Marilou Chanel

Johannes Ranke

Sofia Kaisaridi

Lucie Fayette

createSaemixObject function

<dl><dt>model</dt>
<dd>an saemixModel object</dd>
<dt>data</dt>
<dd>an saemixData object</dd>
<dt>control</dt>
<dd>a list of options (if empty, will be set to the default values by <code>saemixControl</code>)</dd></dl>

Arguments

Create saemix objects with only data filled in — createSaemixObject

<dl>

<dt>model</dt>
<dd>an saemixModel object</dd>


<dt>data</dt>
<dd>an saemixData object</dd>


<dt>control</dt>
<dd>a list of options (if empty, will be set to the default values by <code>saemixControl</code>)</dd>

</dl>

Create saemix objects with only data filled in

createSaemixObject: Create saemix objects with only data filled in

Description

Usage

Value

Arguments

Details

Examples