PocockBound: Pocock (fixed) Bound for the cumulative Z-test with a final target alpha-value
Description
Cumulative alpha values with cumulative hypothesis test with a fixed upper bound z-value in group sequential design.
Usage
PocockBound(K=2, alpha=0.05, side=2)
Value
a fixed upper bound z-value for the K times repated hypothesis test with a final alpha-value.
Attributes are;
ti
time of test, Even-interval is assumed.
cum.alpha
cumulative alpha valued
Arguments
K
total number of tests
alpha
alpha value at the final test
side
1=one-side test, 2=two-side test
Author
Kyun-Seop Bae k@acr.kr
Details
Pocock suggested a fixed upper bound z-value for the cumulative hypothesis test in group sequential designs.
References
Reboussin DM, DeMets DL, Kim K, Lan KKG. Computations for group sequential boundaries using the Lan-DeMets function method. Controlled Clinical Trials. 2000;21:190-207.