sigQC

This directory contains source code, sample code, and a vignette describing the methodology for gene signature quality control as defined by the sigQC methodology.

The method is described in detail in protocol format at https://www.nature.com/articles/s41596-019-0136-8, in the article ``Guidelines for using sigQC for systematic evaluation of gene signatures'' by Andrew Dhawan, Alessandro Barberis, Wei-Chen Cheng, Enric Domingo, Catharine West, Tim Maughan, Jacob Scott, Adrian L. Harris, and Francesca M. Buffa.

If using, please cite our work as follows:

Dhawan, Andrew, Alessandro Barberis, Wei-Chen Cheng, Enric Domingo, Catharine West, Tim Maughan, Jacob G. Scott, Adrian L. Harris, and Francesca M. Buffa. ``Guidelines for using sigQC for systematic evaluation of gene signatures.'' Nature protocols 14, no. 5 (2019): 1377-1400.