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snapCGH (version 1.42.0)

heatmapGenome: clustering and heatmap

Description

This function clusters samples and shows their heatmap

Usage

heatmapGenome(input, response = as.factor(rep("All", ncol(input))), chrominfo = chrominfo.Mb, cutoff = 1, lowCol = "blue", highCol = "yellow", midCol = "white", ncolors = 50, byclass = FALSE, showaber = FALSE, amplif = 1, homdel = -0.75, samplenames = colnames(input), vecchrom = 1:22, titles = "Image Plot", methodS = "ward", categoricalPheno = TRUE, CENTROMERE = FALSE)

Arguments

input
object of class MAList or SegList
response
phenotype of interest. defaults to the same phenotype assigned to all samples
chrominfo
a chromosomal information associated with the mapping of the data
cutoff
maximum absolute value. all the values are floored to +/-cutoff depending on whether they are positive of negative. defaults to 1
ncolors
number of colors in the grid. input to maPalette. defaults to 50
lowCol
color for the low (negative) values. input to maPalette. defaults to "red"
highCol
color for the high (positive) values. input to maPalette. defaults to "green"
midCol
color for the values close to 0. input to maPalette. defaults to "black"
byclass
logical indicating whether samples should be clustered within each level of the phenotype or overall. defaults to F
showaber
logical indicating whether high level amplifications and homozygous deletions should be indicated on the plot. defaults to F
amplif
positive value that all observations equal or exceeding it are marked by yellow dots indicating high-level changes. defaults to 1
homdel
negative value that all observations equal or below it are marked by light blue dots indicating homozygous deletions. defaults to -0.75
samplenames
sample names
vecchrom
vector of chromosomal indeces to use for clustering and to display. defaults to 1:23
titles
plot title. defaults to "Image Plots"
methodS
clustering method to cluster samples. defaults to "ward"
categoricalPheno
logical indicating whether phenotype is categorical. Continuous phenotypes are treated as "no groups" except that their values are dispalyed.defaults to TRUE.
CENTROMERE
logical indicating whether to plot the centromere

Details

This functions is a more flexible version of the heatmap. It can cluster within levels of categorical phenotype as well as all of the samples while displaying phenotype levels in different colors. It also uses any combination of chromosomes that is requested and clusters samples based on these chromosomes only. It draws the chromosomal boundaries and displays high level changes and homozygous deletions. If phenotype if not categorical, its values may still be displayed but groups are not formed and byclass = F. Image plot has the samples reordered according to clustering order.

See Also

heatmap