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sumFREGAT (version 1.2.5)

Fast Region-Based Association Tests on Summary Statistics

Description

An adaptation of classical region/gene-based association analysis techniques to the use of summary statistics (P values and effect sizes) and correlations between genetic variants as input. It is a tool to perform the most popular and efficient gene-based tests using the results of genome-wide association (meta-)analyses without having the original genotypes and phenotypes at hand. See for details: Svishcheva et al (2019) Gene-based association tests using GWAS summary statistics. Bioinformatics. Belonogova et al (2022) SumSTAAR: A flexible framework for gene-based association studies using GWAS summary statistics. PLOS Comp Biol.

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Version

Install

install.packages('sumFREGAT')

Monthly Downloads

281

Version

1.2.5

License

GPL-3

Maintainer

Nadezhda M Belonogova

Last Published

June 7th, 2022

Functions in sumFREGAT (1.2.5)

sumFREGAT-package

sumFREGAT: Fast REGional Association Tests on summary statistics
gene-based test functions

Gene-based tests on summary statistics
ACATO

omnibus aggregated Cauchy association test
prep.score.files

Prepare score files
sumSTAAR

variant-Set Test for Association using Annotation infoRmation on summary statistics