colon: Chemotherapy for Stage B/C colon cancer

Description

These are data from one of the first successful trials of adjuvant chemotherapy for colon cancer. Levamisole is a low-toxicity compound previously used to treat worm infestations in animals; 5-FU is a moderately toxic (as these things go) chemotherapy agent. There are two records per person, one for recurrence and one for death

Usage

colon

Arguments

format

ll{ id: id study: 1 for all patients rx: Treatment - Obs(ervation), Lev(amisole), Lev(amisole)+5-FU sex: 1=male age: in years obstruct: obstruction of colon by tumour perfor: perforation of colon adhere: adherence to nearby organs nodes: number of lymph nodes with detectable cancer time: days until event or censoring status: censoring status differ: differentiation of tumour (1=well, 2=moderate, 3=poor) extent: Extent of local spread (1=submucosa, 2=muscle, 3=serosa, 4=contiguous structures) surg: time from surgery to registration (0=short, 1=long) node4: more than 4 positive lymph nodes etype: event type: 1=recurrence,2=death }

References

JA Laurie, CG Moertel, TR Fleming, HS Wieand, JE Leigh, J Rubin, GW McCormack, JB Gerstner, JE Krook and J Malliard. Surgical adjuvant therapy of large-bowel carcinoma: An evaluation of levamisole and the combination of levamisole and fluorouracil: The North Central Cancer Treatment Group and the Mayo Clinic. J Clinical Oncology, 7:1447-1456, 1989.

DY Lin. Cox regression analysis of multivariate failure time data: the marginal approach. Statistics in Medicine, 13:2233-2247, 1994.

CG Moertel, TR Fleming, JS MacDonald, DG Haller, JA Laurie, PJ Goodman, JS Ungerleider, WA Emerson, DC Tormey, JH Glick, MH Veeder and JA Maillard. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. New England J of Medicine, 332:352-358, 1990.

CG Moertel, TR Fleming, JS MacDonald, DG Haller, JA Laurie, CM Tangen, JS Ungerleider, WA Emerson, DC Tormey, JH Glick, MH Veeder and JA Maillard, Fluorouracil plus Levamisole as and effective adjuvant therapy after resection of stage II colon carcinoma: a final report. Annals of Internal Med, 122:321-326, 1991.