liver

Liver related laboratory data from a randomized, blind, parallel group
clinical trial with 4 doses of a drug.

datasets

Statistical extreme value modelling of threshold excesses, maxima
and multivariate extremes. Univariate models for threshold excesses and maxima
are the Generalised Pareto, and Generalised Extreme Value model respectively.
These models may be fitted by using maximum (optionally penalised-)likelihood,
or Bayesian estimation, and both classes of models may be fitted with covariates
in any/all model parameters. Model diagnostics support the fitting process.
Graphical output for visualising fitted models and return level estimates is
provided. For serially dependent sequences, the intervals declustering algorithm
of Ferro and Segers (2003) <doi:10.1111/1467-9868.00401> is provided, with
diagnostic support to aid selection of threshold and declustering horizon.
Multivariate modelling is performed via the conditional approach of Heffernan
and Tawn (2004) <doi:10.1111/j.1467-9868.2004.02050.x>, with graphical tools for
threshold selection and to diagnose estimation convergence.

Harry Southworth

texmex

Statistical Modelling of Extreme Values

Yiannis Papastathopoulos

Alec Stephenson

Stuart Coles

liver function

A data frame with 606 observations on the following 9 variables.<dl><dt>ALP.B</dt>
<dd>Alkaline phosphatase at baseline. A numeric vector.</dd><dt>ALT.B</dt>
<dd>Alanine aminotransferase at baseline. A numeric vector.</dd><dt>AST.B</dt>
<dd>Aspartate aminotransferase at baseline. A numeric vector.</dd><dt>TBL.B</dt>
<dd>Total bilirubin at baseline. A numeric vector.</dd><dt>ALP.M</dt>
<dd>Alkaline phosphatase after treatment. A numeric vector.</dd><dt>ALT.M</dt>
<dd>Alanine aminotransferase after treatment. A numeric vector.</dd><dt>AST.M</dt>
<dd>Aspartate aminotransferase after treatment. A numeric vector.</dd><dt>TBL.M</dt>
<dd>Total bilirubin after treatment. A numeric vector.</dd><dt>dose</dt>
<dd>The treatment group (i.e. dose group). A factor with levels <code>A</code> <code>B</code> <code>C</code> <code>D</code></dd>
</dl>

Format

Liver related laboratory data — liver

A data frame with 606 observations on the following 9 variables.<dl>

<dt>ALP.B</dt>
<dd>Alkaline phosphatase at baseline. A numeric vector.</dd>

<dt>ALT.B</dt>
<dd>Alanine aminotransferase at baseline. A numeric vector.</dd>

<dt>AST.B</dt>
<dd>Aspartate aminotransferase at baseline. A numeric vector.</dd>

<dt>TBL.B</dt>
<dd>Total bilirubin at baseline. A numeric vector.</dd>

<dt>ALP.M</dt>
<dd>Alkaline phosphatase after treatment. A numeric vector.</dd>

<dt>ALT.M</dt>
<dd>Alanine aminotransferase after treatment. A numeric vector.</dd>

<dt>AST.M</dt>
<dd>Aspartate aminotransferase after treatment. A numeric vector.</dd>

<dt>TBL.M</dt>
<dd>Total bilirubin after treatment. A numeric vector.</dd>

<dt>dose</dt>
<dd>The treatment group (i.e. dose group). A factor with levels <code>A</code> <code>B</code> <code>C</code> <code>D</code></dd>


</dl>

liver: Liver related laboratory data

Description

Usage

Arguments

Format

Details