Several distinct genetic mechanisms lead to acute lymphocytic leukemia (ALL) malignant transformations deriving
from distinct lymphoid precursor cells that have been committed to either T-lineage or B-lineage differentiation.
Chromosome translocations and molecular rearrangements are common events in B-lineage ALL and reflect distinct
mechanisms of transformation. The B cell Receptor (BCR/ABL) gene rearrangement occurs in about 25% of cases in
adult ALL, and much less frequently in pediatric ALL.
y2 dataset contains gene expression signatures of BCR signaling pathway (composed by 35 gene products, n.columns = 35)
in acute lymphocytic leukemia (ALL) cells not associated with BCR/ABL gene rearrangement (n. rows = 41).
Expression values are normalized according to rma and quantile
normalization.
Chiaretti S., Li X., Gentleman R., Vitale A., Wang K.S., Mandelli F., Fo R., Ritz J. (2005) Gene expression profiles of B-lineage adult acute lymphocytic leukemia reveal genetic patterns that identify lineage derivation and distinct mechanisms of transformation. Clin Cancer Res, 11:7209-7219. https://aacrjournals.org/clincancerres/article/11/20/7209/188537/Gene-Expression-Profiles-of-B-lineage-Adult-Acute
Massa, M.S., Chiogna, M., Romualdi, C. (2010). Gene set analysis exploiting the topology of a pathway. BMC Systems Biology, 4:121 https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-4-121