corrMatGenerator

This function generate the correlation matrix for group sequential trials with two endpoints.

The trigger strategy is a general framework for a multistage statistical design with multiple hypotheses, allowing an adaptive selection of interim analyses. The selection of interim stages can be associated with some prespecified endpoints which serve as the trigger. This selection allows us to refine the critical boundaries in hypotheses testing procedures, and potentially increase the statistical power. This package includes several trial designs using the trigger strategy.
See Gou, J. (2023), "Trigger strategy in repeated tests on multiple hypotheses", Statistics in Biopharmaceutical Research, 15(1), 133-140, and Gou, J. (2022), "Sample size optimization and initial allocation of the significance levels in group sequential trials with multiple endpoints", Biometrical Journal, 64(2), 301-311.

Jiangtao Gou

triggerstrategy

Trigger Strategy in Clinical Trials

Fengqing (Zoe) Zhang

corrMatGenerator function

<dl><dt>tp</dt>
<dd>an information fraction vector of Hp</dd>
<dt>ts</dt>
<dd>an information fraction vector of Hs</dd>
<dt>rhops</dt>
<dd>a number that shows the correlation coefficient between the test statistics of the primary endpoint and that of the secondary endpoint</dd></dl>

Arguments

Author

Correlation matrix generator — corrMatGenerator

<dl>

<dt>tp</dt>
<dd>an information fraction vector of Hp</dd>


<dt>ts</dt>
<dd>an information fraction vector of Hs</dd>


<dt>rhops</dt>
<dd>a number that shows the correlation coefficient between the test statistics of the primary endpoint and that of the secondary endpoint</dd>

</dl>

corrMatGenerator: Correlation matrix generator

Description

Usage

Value

Arguments

Author

Examples