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upndown (version 0.2.0)

Utilities and Design Aids for Up-and-Down Dose-Finding Studies

Description

Up-and-Down is the most popular design approach for dose-finding, but has been severely under-served by the statistical computing community. This is the first package to address Up-and-Down's needs. For a recent methodological tutorial on Up-and-Down, see Oron et al. (2022) .

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Version

Install

install.packages('upndown')

Monthly Downloads

147

Version

0.2.0

License

GPL-2

Maintainer

Assaf P. Oron

Last Published

December 10th, 2024

Functions in upndown (0.2.0)

k2targ

Up-and-Down Target Calculation and Design Guidance
dfboot

Generic percentile dose-response / dose-finding bootstrap routine
pivec

Key Probability Vectors of Up-and-Down Designs
bcdmat

Transition Probability Matrices for Up-and-Down Designs
drplot

Visualizing the dose-response summary of an up-and-down experiment
dixonmood

Original Dixon and Mood (1948) point estimate
reversmean

Reversal-anchored averaging estimators for Up-and-Down
krow

Up-and-Down Design Rules for use in Dose-Finding Simulator
dynamean

Up-and-Down target-dose averaging estimate, with dynamic cutoff-point
dfsim

Generalized Dose-Finding Ensemble Simulator
udplot

Visualizing the time series of an up-and-down experiment
udest

Centered-Isotonic-Regression (CIR) Estimate for the Up-and-Down Target Dose
validUDinput

Data Validation Utilities for upndown