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vici - Vaccine Induced Cellular Immunogenicity with Bivariate Modeling

vici encapsulate a shiny app for accurate estimation of vaccine induced immunogenicity with bivariate linear modeling.

Lhomme E, Hejblum BP, Lacabaratz C, Wiedemann A, Lelièvre JD, Lévy Y, Thiébaut R, Richert L (2020). Analyzing cellular immunogenicity in vaccine clinical trials: a new statistical method including non-specific responses for accurate estimation of vaccine effect. Journal of Immunological Methods, 477:112711. doi:10.1016/j.jim.2019.112711.

Installation

You can install the released version of vici from the CRAN with:

install.packages("vici")

or get the development version from GitHub:

#install.packages("remotes")
remotes::install_github("sistm/vici", ref = "file_version")

Then you can launch the app with:

vici::run_app()

Deployed VICI

– Boris Hejblum

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Version

Install

install.packages('vici')

Monthly Downloads

140

Version

0.7.3

License

GPL-3

Last Published

February 2nd, 2024

Functions in vici (0.7.3)

waldCI

Compute Wald Confidence Interval
qform

Compute Quadratic Form
rbindall

rbind Multiple Objects
mygls

Our generalized least squares ls function
myDownloadHandlerForPlots

Custom download handler for plots
boxplot_VICI

Plotting function for displaying boxplots and associated p-values
ddf_BW

Between-Within functions to obtain Denominator degrees of freedom
mod_modelfit_ui

mod_modelfit_ui and mod_modelfit_server
compute_jaclist

Compute_jaclist quantities needed for the Satterthwaite approximation.
mod_settings_pan_ui

mod_settings_pan_ui and mod_settings_pan_server
heatmap_vici

A heatmap function for displaying
get_coefmat_gls

Functions to obtain coefficient, degree of freedom, p-value
ICS_ex

Toy data to upload in the app.
devfun_gls

Compute Full Deviance
histogram_VICI

Plotting function for displaying histograms and associated p-values
interarm_fit

Fitting GLS For Inter-Arm Setting
intraarm_fit

Fitting GLS For Intra-Arm Setting
run_app

Launch VICI Shiny App
varBetafun_gls

Compute covariance of Beta for a Generalized Least Squares (GLS) Model