mixmeta (version 1.2.0)

p53: Mutant p53 Gene and Squamous Cell Carcinoma

Description

The dataset includes studies providing evidence about whether the presence of mutant p53 tumour suppressor gene is a prognostic factor for patients presenting with squamous cell carcinoma arising from the oropharynx cavity. Unadjusted estimates of log hazard ratios of mutant p53 to normal p53 for disease-free and overall survival, together with the associated variances, are collected from 6 observational studies.

Usage

p53

Format

A data frame with 6 observations on the following 5 variables:

• study: study ID.

• y1, V1: estimate and associated variance of the log hazard ratio for disease-free survival.

• y2, V2: estimate and associated variance of the log hazard ratio for overall survival.

Details

Only 3 studies provide estimates for disease-free survival. The within-study correlations are not reported in the original studies but are expected to be highly positively correlated. The original data are described in Tandon and colleagues (2010) and used as an example by Jackson and colleagues (2011).

Examples

# NOT RUN {
### REPRODUCE THE RESULTS OF EXAMPLE 3 IN JACKSON ET AL. (2011)

# INSPECT THE DATA
p53

# REML MODEL WITH INPUTTED CORRELATION EQUAL TO 0.95
model <- mixmeta(cbind(y1,y2), cbind(V1,V2), data=p53, control=list(Scor=0.95))
print(summary(model), digits=2)
# }