This data is a continuation of the PBC data set (pbc),
and contains the follow-up laboratory data for each study patient.
An analysis based on the data can be found in Murtagh et al. (1994).
The primary PBC data set contains only baseline measurements of the laboratory paramters. This data set contains multiple laboratory results, but only on the 312 randomized patients. Some baseline data values in this file differ from the original PBC file, for instance, the data errors in prothrombin time and age which were discovered after the orignal analysis (see Fleming and Harrington, 1991, figure 4.6.7).
data(PBCseq)a data frame with 1 945 rows and the following variables
identification number of a patient
0/1 for male and female
factor of above
0/1 for placebo and D-penicillamine
factor of above
age at entry in years
total number of follow up days
number of days when the patient is known to be alive and without liver transplantation
status at endpoint, 0/1/2 for censored, liver transplant, dead
factor of above
0/1 censoring indicator for event = death (i.e., liver transplantation means censoring)
0/1 censoring indicator for event = death or liver transplantation
number of days between enrollment and this visit date (all measurements below refer to this date)
number of months between enrollment and this visit date
0/1 presence of ascites
factor of above
0/1 presence of hepatomegaly or enlarged liver
factor of above
0/1 presence of blood vessel malformations in the skin
factor of above
presence and status of edema, 0 for no edema, 0.5 for untreated or successfully treated edema, 1 for edema despite diuretic therapy
factor of above
histologic stage of disease (needs biopsy)
factor of above
serum bilirubin (mg/dl)
natural logarithm of above
serum albumin (mg/dl)
natural logarithm of above
alkaline phosphotase (U/liter)
natural logarithm of above
serum cholesterol (mg/dl)
natural logarithm of above
serum glutamic-oxaloacetic transaminase (the enzyme name has subsequently changed to “ALT” in the medical literature) (U/ml)
natural logarithm of above
platelet count
natural logarithm of above
standardised blood clotting time
natural logarithm of above
Dickson, E. R., Grambsch, P. M., Fleming, T. R., Fisher, L. D., and Langworthy, A. (1989). Prognosis in primary biliary-cirrhosis -- Model for decision-making. Hepatology, 10, 1--7.
Fleming, T. R. and Harrington, D. P. (1991). Counting Processes and Survival Analysis. New York: John Wiley and Sons.
Markus, B. H., Dickson, E. R., Grambsch, P. M., Fleming, T. R., Mazzaferro, V., Klintmalm, G. B. G., Wiesner, R. H., Vanthiel, D. H., and Starzl, T. E. (1989). Efficacy of liver-transplantation in patients with primary biliary-cirrhosis. New England Journal of Medicine, 320, 1709--1713.
Murtaugh, P. A., Dickson, E. R., Van Dam, G. M., Malinchoc, M., Grambsch, P. M., Langworthy, A. L., and Gips, C. H. (1994). Primary biliary cirrhosis: Prediction of short-term survival based on repeated patient visits. Hepatology, 20, 126-134.
Therneau, T. M. and Grambsch, P. M. (2000). Modeling Survival Data: Extending the Cox Model. New York: Springer-Verlag.