Computes weighted topological overlap following
the Novick et al. (2009) definition
Usage
wto(network, signed = TRUE, diagonal.zero = TRUE)
Value
A symmetric matrix of weighted topological overlap
values between each pair of variables
Arguments
network
Symmetric matrix or data frame.
A symmetric network
signed
Boolean (length = 1).
Whether the signed version should be used.
Defaults to TRUE.
Use FALSE for absolute values
diagonal.zero
Boolean (length = 1).
Whether diagonal of overlap matrix should be set to zero.
Defaults to TRUE.
Use FALSE to allow overlap of a node with itself
References
Original formalization
Nowick, K., Gernat, T., Almaas, E., & Stubbs, L. (2009).
Differences in human and chimpanzee gene expression patterns define an evolving network of transcription factors in brain.
Proceedings of the National Academy of Sciences, 106, 22358-22363.