AvgCorr

<p>Force correlation estimate to fall in the interval (a,1-a);</p>

<p>Estimate correlation using the average of qnorm(p1)*qnorm(p2) across loci, where
(p1,p2) are p-values obtained via two different association tests.</p>

Implementation of genetic association tests based on the rank based inverse normal transformation (INT). The primary contribution is an omnibus test, which synthesizes two complementary INT-based approaches. In simulations against phenotypes with skewed and heavy tailed residual distributions, the omnibus test provided valid inference in the absence of a genotypic effect, and provided power comparable to the more powerful of the component methods in the presence of a genotypic effect. Under these settings, standard linear regression often failed to control the type I error.

Zachary McCaw

AvgCorr: Average Correlation Estimate.

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