BootCorr

Offset applied during rank-normalization. See
<code><a rd-options="" href="/link/rankNormal?package=RNOmni&version=0.3.0" data-mini-rdoc="RNOmni::rankNormal">rankNormal</a></code>.

Bootstrap samples for correlation estimation.

Run bootstraps in parallel? Must register parallel backend first.

parallel

Use bootstrap to estimate correlation among Z statistics
whose maximum is taken in the omnibus test.

Implementation of genetic association tests based on the rank based inverse normal transformation (INT). The primary contribution is an omnibus test, which synthesizes two complementary INT-based approaches. In simulations against phenotypes with skewed and heavy tailed residual distributions, the omnibus test provided valid inference in the absence of a genotypic effect, and provided power comparable to the more powerful of the component methods in the presence of a genotypic effect. Under these settings, standard linear regression often failed to control the type I error.

Zachary McCaw

RNOmni

Omnibus Test for Genetic Association Analysis using the Rank
Normal Transformation

BootCorr function

Offset applied during rank-normalization. See
<code><a rd-options='' href='rankNormal'>rankNormal</a></code>.

BootCorr: Bootstrap Correlation Estimate.

Description

Usage

Arguments