AvgCorr

Threshold Z score above which the p-value likely corresponds to a true positive.

Force correlation estimate to fall in the interval (a,1-a);

Estimates the correlation between correlated p-values on the Z-score scale. The
p-values are supposed to have arisen from different tests of the same hypothesis
using the same data. Since an estimate of correlation under the null is of interest,
pairs where at least one of the Z scores exceeds the threshold \(\tau\) are excluded.

Implementation of genetic association tests using the rank based inverse normal transformation (INT). The primary contribution is an omnibus test, which synthesizes two complementary INT-based approaches. In simulations against phenotypes with skewed and heavy tailed residuals, the omnibus test provided valid inference in the absence of genetic effects. When genetic effects were present, the omnibus test provided power comparable to the more efficient of the component methods. Under these settings, standard linear regression variously failed to control the type I error in the absence of genetic effects, and was underpowered in the presence of genetic effects.

Zachary McCaw

AvgCorr: Average Correlation Estimate.

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