RNOmni-help

RNOmni-help-package

<p>Implementation of genetic association tests that utilize the rank-based inverse
normal transformation (INT). The main function is <code><a rd-options="" href="/link/RNOmni?package=RNOmni&version=0.5.0" data-mini-rdoc="RNOmni::RNOmni">RNOmni</a></code>, which performs
an omnibus, INT-based association test. The omnibus test combines the direct <code><a rd-options="" href="/link/DINT?package=RNOmni&version=0.5.0" data-mini-rdoc="RNOmni::DINT">DINT</a></code>
and indirect <code><a rd-options="" href="/link/IINT?package=RNOmni&version=0.5.0" data-mini-rdoc="RNOmni::IINT">IINT</a></code> INT-based tests. The transformation itself is described 
under <code><a rd-options="" href="/link/rankNorm?package=RNOmni&version=0.5.0" data-mini-rdoc="RNOmni::rankNorm">rankNorm</a></code>. See the vignette for additional details.</p>

Implementation of genetic association tests for continuous outcomes utilizing the rank-based inverse normal transformation (INT). For outcomes whose residual distribution is heavily skewed or enriched for outliers, INT-based tests provided valid inference and improved power. The primary contribution is a rank normal omnibus test (RNOmni), which synthesizes two complementary INT-based approaches. In simulations against non-normal phenotypes, the omnibus test controlled the type I error in the absence of genetic associations, and improved power in the presence of genetic associations. Under the same settings, standard linear regression variously failed to control the type I error in the absence of associations, and was underpowered in the presence of associations.

Zachary McCaw

RNOmni

Omnibus Test for Genetic Association Analysis using the Rank
Normal Transformation

RNOmni-help function

<p>Implementation of genetic association tests that utilize the rank-based inverse
normal transformation (INT). The main function is <code><a rd-options='' href='RNOmni'>RNOmni</a></code>, which performs
an omnibus, INT-based association test. The omnibus test combines the direct <code><a rd-options='' href='DINT'>DINT</a></code>
and indirect <code><a rd-options='' href='IINT'>IINT</a></code> INT-based tests. The transformation itself is described 
under <code><a rd-options='' href='rankNorm'>rankNorm</a></code>. See the vignette for additional details.</p>

RNOmni-help: RNOmni: Rank-Normal Omnibus Association Test

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