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<p>Implementation of genetic association tests that incorporate the rank-based inverse
normal transformation (INT) <code><a rd-options="" href="/link/rankNorm?package=RNOmni&version=0.6.0" data-mini-rdoc="RNOmni::rankNorm">rankNorm</a></code>. The direct-INT <code><a rd-options="" href="/link/DINT?package=RNOmni&version=0.6.0" data-mini-rdoc="RNOmni::DINT">DINT</a></code> test directly
transforms the outcome, whereas the indirect-INT <code><a rd-options="" href="/link/IINT?package=RNOmni&version=0.6.0" data-mini-rdoc="RNOmni::IINT">IINT</a></code> test forms residuals prior to transformation. 
The omnibus INT <code><a rd-options="" href="/link/OINT?package=RNOmni&version=0.6.0" data-mini-rdoc="RNOmni::OINT">OINT</a></code> test adaptively combines the D-INT and I-INT tests into a single
robust and statistically powerful procedure.</p>

Implementation of genetic association tests that incorporate the rank-based inverse normal transformation (INT). These tests are broadly indicated for traits with continuous residual distributions. In the presence of non-normal residuals, INT-based tests robustly control the type I error, whereas standard linear regression may not. Moreover, INT-based tests dominate standard linear regression in terms of power. There are two main strategies for incorporating the INT in association analysis. In direct INT (D-INT), the trait is directly transformed. In indirect INT (I-INT), residuals are formed prior to transformation. Neither D-INT nor I-INT is uniformly most powerful. The INT omnibus test (O-INT) adaptively combines D-INT and I-INT into a single robust and statistically powerful approach.

Zachary McCaw

RNOmni

Rank Normal Transformation Omnibus Test

RNOmni-help function

<p>Implementation of genetic association tests that incorporate the rank-based inverse
normal transformation (INT) <code><a rd-options='' href='rankNorm'>rankNorm</a></code>. The direct-INT <code><a rd-options='' href='DINT'>DINT</a></code> test directly
transforms the outcome, whereas the indirect-INT <code><a rd-options='' href='IINT'>IINT</a></code> test forms residuals prior to transformation. 
The omnibus INT <code><a rd-options='' href='OINT'>OINT</a></code> test adaptively combines the D-INT and I-INT tests into a single
robust and statistically powerful procedure.</p>

RNOmni-help: RNOmni: Rank-Normal Omnibus Association Testing

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