Learn R Programming

cn.mops (version 1.18.0)

cn.mops - Mixture of Poissons for CNV detection in NGS data

Description

cn.mops (Copy Number estimation by a Mixture Of PoissonS) is a data processing pipeline for copy number variations and aberrations (CNVs and CNAs) from next generation sequencing (NGS) data. The package supplies functions to convert BAM files into read count matrices or genomic ranges objects, which are the input objects for cn.mops. cn.mops models the depths of coverage across samples at each genomic position. Therefore, it does not suffer from read count biases along chromosomes. Using a Bayesian approach, cn.mops decomposes read variations across samples into integer copy numbers and noise by its mixture components and Poisson distributions, respectively. cn.mops guarantees a low FDR because wrong detections are indicated by high noise and filtered out. cn.mops is very fast and written in C++.

Copy Link

Version

Version

1.18.0

License

LGPL (>= 2.0)

Maintainer

Guenter Klambauer

Last Published

February 15th, 2017

Functions in cn.mops (1.18.0)

calcIntegerCopyNumbers,CNVDetectionResult-method

Calculation of integer copy numbers for the CNVs and CNV regions.
calcIntegerCopyNumbers

Calculation of integer copy numbers for the CNVs and CNV regions.
getReadCountsFromBAM

Calculation of read counts from BAM files.
iniCall,CNVDetectionResult-method

This generic function returns the informative/non-informative call of a CNV detection method stored in an instance of CNVDetectionResult-class. The I/NI call is a measure for a genomic segment across all samples, whether this segment is a CNV region (informative) or a normal genomic region (non-informative).
exomeCounts

Read counts from exome sequencing for CNV detection
sampleNames

This generic function returns the sample names of a CNV detection method stored in an instance of CNVDetectionResult-class.
iniCall

This generic function returns the informative/non-informative call of a CNV detection method stored in an instance of CNVDetectionResult-class. The I/NI call is a measure for a genomic segment across all samples, whether this segment is a CNV region (informative) or a normal genomic region (non-informative).
segment

Fast segmentation of CNV calls.
cnvr

This generic function returns CNV regions of a CNV detection method stored in an instance of CNVDetectionResult-class.
cnvr,CNVDetectionResult-method

This generic function returns CNV regions of a CNV detection method stored in an instance of CNVDetectionResult-class.
getSegmentReadCountsFromBAM

Calculation of read counts from BAM files for predefined segments.
gr,CNVDetectionResult-method

This generic function returns the genomic ranges of a CNV detection method stored in an instance of CNVDetectionResult-class.
integerCopyNumber,CNVDetectionResult-method

This generic function returns the integer copy numbers of a CNV detection method stored in an instance of CNVDetectionResult-class.
integerCopyNumber

This generic function returns the integer copy numbers of a CNV detection method stored in an instance of CNVDetectionResult-class.
referencecn.mops

Copy number detection in NGS data with in a control versus cases setting.
sampleNames,CNVDetectionResult-method

This generic function returns the sample names of a CNV detection method stored in an instance of CNVDetectionResult-class.
X

A simulated data set for CNV detection from NGS data.
XRanges

A simulated data set for CNV detection from NGS data.
cnvs,CNVDetectionResult-method

This generic function returns CNVs of a CNV detection method stored in an instance of CNVDetectionResult-class.
CNVRanges

Genomic locations and indices of the simulated CNVs.
individualCall,CNVDetectionResult-method

This generic function returns the individual calls of a CNV detection method stored in an instance of CNVDetectionResult-class.
individualCall

This generic function returns the individual calls of a CNV detection method stored in an instance of CNVDetectionResult-class.
normalizeGenome

Normalization of NGS data
params,CNVDetectionResult-method

This generic function returns the parameters of a CNV detection method stored in an instance of CNVDetectionResult-class.
segplot,CNVDetectionResult-method

Visualization of a CNV detection result.
segplot

Visualization of a CNV detection result.
calcFractionalCopyNumbers

Calculation of fractional copy numbers for the CNVs and CNV regions.
cnvs

This generic function returns CNVs of a CNV detection method stored in an instance of CNVDetectionResult-class.
calcFractionalCopyNumbers,CNVDetectionResult-method

Calculation of fractional copy numbers for the CNVs and CNV regions.
exomecn.mops

Copy number detection in exome sequencing data.
makeRobustCNVR

Calculates robust CNV regions.
normalizeChromosomes

Normalization of NGS data.
params

This generic function returns the parameters of a CNV detection method stored in an instance of CNVDetectionResult-class.
plot

Plots a CNVDetectionResult
segmentation,CNVDetectionResult-method

This generic function returns segmentation of a CNV detection method stored in an instance of CNVDetectionResult-class.
segmentation

This generic function returns segmentation of a CNV detection method stored in an instance of CNVDetectionResult-class.
cn.mops

Copy number detection in NGS data.
normalizedData

This generic function returns the normalized data of a CNV detection method stored in an instance of CNVDetectionResult-class.
show

Displays the result object of a copy number detection method.
normalizedData,CNVDetectionResult-method

This generic function returns the normalized data of a CNV detection method stored in an instance of CNVDetectionResult-class.
singlecn.mops

Copy number detection in NGS data with in a setting in which only one sample is available
CNVDetectionResult-class

Class "CNVDetectionResult"
gr

This generic function returns the genomic ranges of a CNV detection method stored in an instance of CNVDetectionResult-class.
haplocn.mops

Copy number detection in NGS data of haploid samples.
localAssessments

This generic function returns the local assessments, i.e. signed individual informative/non-informative calls, of a CNV detection method stored in an instance of CNVDetectionResult-class. For other CNV detection methods this can be (log-) ratios or z-scores.
localAssessments,CNVDetectionResult-method

This generic function returns the local assessments, i.e. signed individual informative/non-informative calls, of a CNV detection method stored in an instance of CNVDetectionResult-class. For other CNV detection methods this can be (log-) ratios or z-scores.
posteriorProbs,CNVDetectionResult-method

This generic function returns the posterior probabilities of a CNV detection method stored in an instance of CNVDetectionResult-class. The posterior probabilities are represented as a three dimensional array, where the three dimensions are segment, copy number and individual.
posteriorProbs

This generic function returns the posterior probabilities of a CNV detection method stored in an instance of CNVDetectionResult-class. The posterior probabilities are represented as a three dimensional array, where the three dimensions are segment, copy number and individual.