mixOmics (version 2.8-1)

liver.toxicity: Liver Toxicity Data

Description

This data set contains the expression measure of 3116 genes and 10 clinical measurements for 64 subjects (rats) that were exposed to non-toxic, moderately toxic or severely toxic doses of acetaminophen in a controlled experiment.

Usage

data(liver.toxicity)

encoding

latin1

Details

The data come from a liver toxicity study (Heinloth et al., 2004) in which 64 male rats of the inbred strain Fisher 344 were exposed to non-toxic (50 or 150 mg/kg), moderately toxic (1500 mg/kg) or severely toxic (2000 mg/kg) doses of acetaminophen (paracetamol) in a controlled experiment. Necropsies were performed at 6, 18, 24 and 48 hours after exposure and the mRNA from the liver was extracted. Ten clinical chemistry measurements of variables containing markers for liver injury are available for each subject and the serum enzymes levels are measured numerically. The data were further normalized and pre-processed by Bushel et al. (2007).

References

Heinloth, A., Irwin, R., Boorman, G., Nettesheim, P., Fannin, R., Sieber, S., Snell, M., Tucker, C., Li, L., Travlos, G., et al. (2004). Gene Expression Profiling of Rat Livers Reveals Indicators of Potential Adverse Effects. Toxicological Sciences 80(1), 193-202.

Bushel, P., Wolfinger, R. D. and Gibson, G. (2007). Simultaneous clustering of gene expression data with clinical chemistry and pathological evaluations reveals phenotypic prototypes. BMC Systems Biology 1, Number 15.

L� Cao, K.-A., Rossouw, D., Robert-Grani�, C. and Besse, P. (2008). A sparse PLS for variable selection when integrating Omics data. Statistical Applications in Genetics and Molecular Biology 7, article 35.