gset_list_from_gmt

Retrieve Gene Sets from GMT-format File

Enrichment analysis enables researchers to uncover mechanisms
underlying a phenotype. However, conventional methods for enrichment
analysis do not take into account protein-protein interaction information,
resulting in incomplete conclusions. 'pathfindR' is a tool for enrichment
analysis utilizing active subnetworks. The main function identifies active
subnetworks in a protein-protein interaction network using a user-provided
list of genes and associated p values. It then performs enrichment analyses
on the identified subnetworks, identifying enriched terms (i.e. pathways or,
more broadly, gene sets) that possibly underlie the phenotype of interest.
'pathfindR' also offers functionalities to cluster the enriched terms and
identify representative terms in each cluster, to score the enriched terms
per sample and to visualize analysis results. The enrichment, clustering and
other methods implemented in 'pathfindR' are described in detail in
Ulgen E, Ozisik O, Sezerman OU. 2019. 'pathfindR': An R Package for
Comprehensive Identification of Enriched Pathways in Omics Data Through
Active Subnetworks. Front. Genet. <doi:10.3389/fgene.2019.00858>.

Ege Ulgen

pathfindR

Enrichment Analysis Utilizing Active Subnetworks

Ozan Ozisik

gset_list_from_gmt function

<dl><dt>path2gmt</dt>
<dd>path to the gmt file</dd>
<dt>descriptions_idx</dt>
<dd>index for descriptions (default = 2)</dd></dl>

Arguments

Retrieve Gene Sets from GMT-format File — gset_list_from_gmt

<dl>

<dt>path2gmt</dt>
<dd>path to the gmt file</dd>


<dt>descriptions_idx</dt>
<dd>index for descriptions (default = 2)</dd>

</dl>

gset_list_from_gmt: Retrieve Gene Sets from GMT-format File

Description

Usage

Value

Arguments