pkr (version 0.1.3)

LogAUC: Area Under the Curve(AUC) and Area Under the first Moment Curve(AUMC) by linear-up log-down method

Description

It calculates AUC and AUMC using linear-up log-down method

Usage

LogAUC(x, y)

Arguments

x

vector values of independent variable, usually time

y

vector values of dependent variable, usually concentration

Value

AUC

area under the curve

AUMC

area under the first moment curve

Details

This function returns AUC and AUMC by linear-up log-down method.

References

1. Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016.

2. Shargel L, Yu A. Applied Biopharmaceutics and Pharmacokinetics. 7th ed. 2015.

3. Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics - Concepts and Applications. 4th ed. 2011.

4. Gibaldi M, Perrier D. Pharmacokinetics. 2nd ed. revised and expanded. 1982.

See Also

LinAUC,AUC

Examples

# NOT RUN {
LogAUC(Theoph[Theoph$Subject==1, "Time"], Theoph[Theoph$Subject==1, "conc"])
# Compare the last line with the above
AUC(Theoph[Theoph$Subject==1, "Time"], Theoph[Theoph$Subject==1, "conc"], down="Log") 
# }